DETAILED PROGRAMME

List of posters

SUNDAY 29. 8. 2021

10:00 – 18:00 REGISTRATION / Foyer Building C
Antigen and PCR test / mobile sampling point in front of the Building C / Institute of Applied Biotechnologies a.s
16:00 – 16:30 Opening Ceremony / Hall A
16:30 – 17:30 Plenary lecture / Hall A
Martin Jínek: CRISPR-Cas genome editors: structures, mechanisms and applications
19:00 – 22:00 Social Evening / South-Bohemian Museum
Historiographical lecture – Radim Černý: German-speaking Physiological Chemists and Biochemists at Charles University in Prague

MONDAY 30. 8. 2021

7:30 – 17:00 REGISTRATION / Foyer Building C
7:30 – 12:00 Antigen and PCR test / mobile sampling point in front of the Building C / Institute of Applied Biotechnologies a.s
8:30 – 9:30 Plenary lecture - J. V. Koštíř Prize Lecture / Hall A
Libor Vítek: Bilirubin in health and disease
9:30 – 10:00 Coffee break
10:00 – 11:30 Pathobiochemistry & Clinical Biochemistry, Cancer – PART I/ Hall A
Chairs:
Radim Černý
Ján Lehotský
10:00 – 10:30 Stanislav Kmoch: On the human genome anatomy and pathology
10:30 - 10:45 Lenka Nosková: Use of whole-exome sequencing in identification of molecular basis of rare pediatric diseases
10:45 - 11:00 Martina Živná: Proteinopathies and activation of endoplasmic reticulum stress as central pathogenetic mechanism in hereditary tubulointerstitial kidney disease
11:00 – 11:30 Zdeněk Kleibl: Germline CHEK2 gene variants in breast cancer predisposition
Cell Signaling, Regulations / Hall C
Chairs:
Tomáš Doležal
Peter Celec
Michael Wrzaczek
10:00 – 10:15 Peter Celec: Aging, neutrophil extracellular traps and severe Covid
10:15 – 10:30 Michael Wrzaczek: Regulation of NOX activity in plant immunity
10:30 – 10:45 Tomáš Doležal: On the origin of adenosine by means of privileged immune cells
10:45 – 11:00 Marek Mráz: GAB1 regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia: novel therapeutic target
11:00 – 11:15 Ondřej Vaněk: Crystal structure of the human natural killer cell receptor NKR-P1 bound to its lymphocyte ligand LLT1 reveals receptor clustering in the immune synapse
11:15 – 11:30 Alexey Bondar: Complexes of G proteins with G protein-coupled receptors at the single-molecule level
Enzymes, Coenzymes, Inhibitors – PART I / Hall B
Chairs:
Kvído Stříšovský
Eva Kutejová
10:00 – 10:30 Cyril Bařinka: Discovery of a new molecular rotor for real-time fluorescence imaging of prostate-specific membrane antigen
10:30 – 10:45 Dmitri Nikitin: Computer-assisted affinity engineering of staphylokinase plasminogen activator protein
10:45 – 11:00 Mohamed Amine Jmel: Biochemical characterization and immunosuppressive activity of Ricistatin, a new salivary cystatin from Ixodes ricinus
11:00 – 11:15 Jakub Vávra: The role of hydrogen sulfide in heme sensor proteins signal transduction following oxidative stress processes
11:30 – 12:30 Lunch / University canteen
12:30 – 14:00 Pathobiochemistry & Clinical Biochemistry, Cancer – PART II/ Hall A
Chairs:
Radim Černý
Ján Lehotský
12:30 – 12:55 Ján Lehotský: Genetics of multiple sclerosis in central Slovak population as preventive individualized approach
12:55 – 13:20 Milan Jirsa: Molecular mechanism of bile secretion and its disorders
13:20 – 13:45 Tomáš Mráček: Disorders of mitochondrial ATP synthase – what can we learn from animal models?
13:45 – 14:00 Alžběta Spálenková: In vitro and in vivo efficacy of novel Stony Brook taxanes in resistant model of ovarian carcinoma
Glycobiochemistry, Postranslational Modifications / Hall C
Chairs:
Michaela Wimmerová
Peter Biely
12:30 – 12:40 Michaela Wimmerová: Welcome, Foreword
12:40 – 13:00 Katarína Šuchová: Xylanases of glycoside hydrolase family 30: structure-function relationship
13:00 – 13:20 Eva Fujdiarová: PLL lectin family from entomopathogenic bacterium Photorhabdus laumondii
13:20 – 13:40 Karin Savková: Functional characterization an ABC transporter Wzm-Wzt involved in the translocation of galactan precursors across the plasma membrane in mycobacteria
13:40 – 14:00 Kateryna Kotsarenko: C-type lectin of tick Ixodes ricinus
Enzymes, Coenzymes, Inhibitors – PART II / Hall B
Chairs:
Kvído Stříšovský
Eva Kutejová
12:30 – 13:00 Tomas Fessl: Mapping allosteric communication in the bacterial translocon
13:00 – 13:15 Henrieta Havalová: The phosphorylation of human lon protease – a key component of protein quality control in mitochondria
13:15 – 13:30 Katerina Brodsky: Novel bacterial aryl sulfotransferase and its use in the study on flavonoid metabolism
13:30 – 13:45 Erik Sedlák: Flavin cofactor in AsLOV2 domain as efficient singlet oxygen producer


14:00 – 15:30 Poster session and refreshment / Foyer Building C
15:30 – 16:30 Plenary lecture / Hall A
Jiří Friml: Rapid auxin signaling for plant growth and development
16:30 – 17:00 ČSBMB committee session

TUESDAY 31. 8. 2021

8:00 – 16.00 REGISTRATION / FOYER Building C
8:30 – 9:30 Plenary lecture / Hall A
Erik De Clercq: In search of an ideal treatment of SARS-CoV-2 infections
9:30 – 10:00 Coffee break
10:00 – 11:30 Biochemistry and Molecular Biology of Viruses, Bacteria & Parasites – PART I / Hall A
Chairs:
Libor Grubhoffer
Anton Horváth
10:00 – 10:15 Roman Tůma: Imaging viral factories of avian reovirus
10:15 – 10:30 Zdeněk Franta: Production and characterization of TBEV replicative enzymes
10:30 – 10:45 Martin Selinger: Novel features of tick-borne encephalitis virus capsid protein
10:45 – 11:00 Paulina Duhita Anindita: Structural snapshots of ATPase cycle of tick-borne encephalitis virus helicase
11:00 – 11:15 Michala Forinová: Rapid detection of SARS-CoV-2 in real-world samples using A-QCM biosensor
11:15 – 12:00 Daniel Sojka: Proteasome as a target to combat ticks and tick-borne diseases
Membranes, Bioenergetics / Hall C
Chairs:
Jan Kopecký
Josef Ukropec
10:00 – 10:15 Kristýna Čunátová: Deficiency in single oxidative phosphorylation system (OXPHOS) complex triggers downregulation of OXPHOS through attenuation of mitochondrial proteosynthesis
10:15 – 10:30 Ondřej Gahura: Dimerisation-dependent cristae shaping and mechanism of rotary catalysis of the Trypanosoma brucei mitochondrial ATP synthase
10:30 – 10:45 Eliška Koňaříková: New factors regulating biogenesis of subunit c from mammalian FoF1 ATP synthase
10:45 – 11:00 Marko Mitrovic: A single bout of exercise increases circulating levels of PAHSA lipokines in lean mice
11:00 – 11:15 Alena Pecinová: Metabolic phenotype and innate immune response in rat conplastic strains
11:15 – 11:30 Sara Stanić: A pyrexic effect of FGF21 independent of energy expenditure and UCP1
Biotechnology / Hall B
Chairs:
Jiří Damborský
Erik Sedlák
10:00 – 10:20 Pavel Dvořák: Upgrading Pseudomonas putida by synthetic biology for biotechnological processing of lignocellulosic substrates
10:20 – 10:35 Viktoria Heine: Immunoprotective glycomimetic-neo-glycoproteins as inhibitors of galectin-3
10:35 – 10:50 Josef Houser: Development of 48 condition buffer screen for protein stability assessment
10:50 – 11:10 Kateřina Sipošová: Detergents and phospholipids in relation to amyloidogenesis: could be interchangeable?
11:10 – 11:30 Zora Nováková: Protein engineering of antibody 5D3 intended for prostate cancer imaging and therapy


11:30 – 12:30 Lunch / University canteen


12:30 – 14:00 Biochemistry and Molecular Biology of Viruses, Bacteria & Parasites – PART II / Hall A
Chairs:
Libor Grubhoffer
Anton Horváth
12:30 – 12:45 Alena Zíková: Revising the neglected mitochondrial energy metabolism of the human pathogen, Trypanosoma brucei
12:45 – 13:00 Anton Horváth: NADH:ubiquinone oxidoreductase in trypanosomatids
13:00 – 13:15 Julie Kovářová: Gluconeogenesis in the bloodstream form of trypanosoma brucei
13:15 – 13:30 Karel Kopejtka: Simultaneous presence of bacteriochlorophyll and xanthorhodopsin genes in a freshwater bacterium
13:30 – 13:45 Martin Kryl: ArsH enzyme encoded by the ars operons of paracoccus denitrificans: expression, purification, crystallization, and structure determination via molecular replacement
13:45 - 14:00 Jiří Pospíšil: Mystery of bacterial nanotubes revealed
Marie Stiborová Memorial Symposium on Xenobiochemistry / Hall B
Chairs:
Pavel Anzenbacher
Albert Breier
12:30 - 12:40 Pavel Anzenbacher: Xenobiochemistry and Marie Stiborová
12:40 – 13:00 Pavel Souček: From biochemistry to molecular oncology and back
13:00 – 13:15 Alena Dědíková: Aristolochic acid II influences the metabolism of carcinogenic aristolochic acid I, thereby enhancing its genotoxicity
13:15 – 13:30 Martin Cagala: Development of resistance to endoplasmic reticulum stress- inducing agents in mouse leukemic L1210 Cells
13:30 – 13:45 Petra Olejníková: Antifungal agents – xenobiotics to fungi
13:45 – 14:00 Lenka Jourová: Microbial metabolites, gut microbiome and hepatic cytochromes P450
Emil Paleček Memorial Symposium on Bioelectrochemistry / Hall C
Chairs:
Miroslav Fojta
Ján Tkáč
12:30 – 12:40 Miroslav Fojta: Recent progress in nucleic acid electrochemistry: behavior of homonucleotide blocks and roles of catalytic hydrogen evolution
12:40 – 12:55 Veronika Ostatná: Catalytic hydrogen evolution reaction in analysis of biomolecules and their complexes
12:55 – 13:15 Michal Cifra: Modifying structure and function of tubulin and microtubules by intense nanosecond electric field
13:15 – 13:35 Petr Skládal: Biosensors – where are the limits
13:35 – 13:50 Jan Vácek: Redox properties of electrophilic nitro-fatty acids and their siomolecular interactions
13:50 – 14:00 Ján Tkáč: Nanotechnology-based biosensing: Application in cancer diagnostics
14:00 – 15:30 Poster session and refreshment
15:30 – 16:30 Plenary lecture / Hall A
Rolf Hilgenfeld: A structural view of the SARS-CoV-2 replication cycle and the opportunities it offers for antiviral drug discovery


18:30 – 23:00 Social programme - South Bohemian Theatre - Performance of the Dejvické Theatre Prague „The Elegance of the Molecule “

WEDNESDAY 1. 9. 2021

8:00 – 14:00 REGISTRATION
8:30 – 9:30 Plenary lecture / Hall A
Vladimír Beneš: Single-cell transcriptomics – getting there but not entirely there yet
9:30 – 10:00 Coffee break
10:00 – 11:30 DNA, RNA, Gene Expression, Epigenetics / Hall A
Chairs:
Petr Svoboda
Imrich Barák
10:00-10:20 Imrich Barák: Nucleoid organization as a cue of asymmetric septum positioning in bacillus subtilis
10:20-10:30 Gabriel Demo: Cryo-EM ensemble captures EF-G mediated ribosomal translocation in action
10:30-10:50 Hana Macickova-Cahova: Dinucleoside polyphosphates act as 5’ RNA caps in bacteria
10:50-11:00 Jarmila Hnilicová: Novel RNA molecules interacting with the bacterial transcription machinery
11:00-11:20 Petr Fajkus: Extensive characterisation of telomerase RNAs across the phylogenetic megagroup diaphoretickes shows their common origin more than a billion years ago
11:20-11:30 Jan Paleček: The architecture of the human SMC5/6 complex
Computational Biochemistry, Molecular Modeling / Hall C
Chairs:
David Řeha
Vojtěch Spiwok
10:00 – 10:15 Zdeněk Futera: Biomolecular Interfaces with metal electrodes - structure, electronic properties and their response to external electric field
10:15 – 10:30 Stanislav Kozmon: Xyloglucan endotransglycosylase (XET) substrate interactions study
10:30 – 10:45 Michal H. Kolář: Peptide deformylase as a probe of long-range allostery between ribosome surface and interior
10:45 – 11:00 Robert Vácha: Genome release from non-enveloped RNA viruses: capsid rupture or pore formation
Bioinformatics / Hall C
Chairs:
Radka Svobodová Vařeková
Jiří Vondrášek
11:00 – 11:20 Jan Velecký: SoluProtMutDB: Mutation Database for Protein Solubility Engineering
Biochemistry and Molecular Biology of Plants / Hall B
Chairs:
František Vácha
Olga Valentová
10:00 – 10:13 Michal Koblížek: 2.4 Å structure of the double concentric ringed light harvesting complex from phototrophic bacterium Gemmatimonas phototrophica
10:13 – 10:26 Tomáš Bilý: 3D reconstruction of Chlorosome lamellar subdomain
10:26 – 10:39 Alastair Thomas Gardiner: The cryo-EM structure of the LH2 complex from Marichromatium purpuratum at 2.4 Å
10:39 – 10:52 Zoltán Polozsányi: Biological effects of glucosinolate degradation products from Cardaria draba
10:52 – 11:05 Hendrik Küpper: Mechanisms of sublethal cadmium toxicity in plants
11:05 – 11:18 Marek Petřivalský: Unravelling the role of reactive oxygen species and nitric oxide in structure-activity relationships of elicitins
11:18 – 11:30 Martin Janda: Disrupted actin: a novel player in pathogen attack sensing?


11:30 – 12:30 Lunch / University canteen


12:30 – 14:00 Proteomics / Hall A
Chairs:
Petr Novák
L'udovít Škultéty
12:30 – 12:45 Fernando Zúñiga-Navarrete: Discovery proteomics proposes a tolerance mechanism maintaining the survival of coxiella burnetii under doxycycline exposure
12:45 – 13:00 Lucia Janáčová: Tumor suppressor role of catechol O-methyl transferase in estrogen receptor positive breast cancer through inhibition of cell invasion via MET signaling
13:00 – 13:15 Zdeněk Spáčil: Quantitative proteomics of neural tissue cell-specific markers
13:15 – 13:30 Roman Tuzhilkin: Azurin: a model metalloprotein to study an electron transfer process
13:30 – 13:45 Dmitry Loginov: Hydroxyl radical footprinting analysis of a human haptoglobin- hemoglobin complex using timsTOF Pro
13:45 – 14:00 Jan Fiala: Mass spectrometric approach for the study of in-solution dynamics of proteins and protein-DNA complexes
Teaching in Biochemistry and Biological Chemistry study programs / Hall C
Chairs:
Ján Štěrba
Adriana Rathner
12:30 - 12:35 Ján Štěrba: opening
12:35 - 12:45 Michal Kamenický: Cross border life science education: Biological chemistry
12:45 - 12:56 Martin Strnad: Biological chemistry graduate’s viewpoint
12:56 - 13:05 Ondřej Cihlář: Biological chemistry current student’s viewpoint
13:05 - 13:20 Lenka Malinovská: New “blood” in lectin research


Lectures by Biological Chemistry program graduates


13:20 - 13:35 Adela Tiffner: Orai1 boosts SK3 currents in prostate cancer cells
13:35 - 13:50 Petr Rathner: NMR investigation of stromal interaction molecule 1
13:50 - 14:00 Vitus Stemmer: Expression and purification of the lumenal domain of CP43, a protein in Photosystem II